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KMID : 0438219770140030493
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Korea University Medical Journal
1977 Volume.14 No. 3 p.493 ~ p.502
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The Effects of Vitamin-E and Iron on Anemia of Infancy and Low-Birth-Weight Infants
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Abstract
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It has been fairly well known that vitamin-E plays a role in hematopoiesis as a supportive factor.
The study has been attempted to determine the effects of vitamin-E and iron supplementation on the anemia of infancy and low-birth-weight infants. The measurements of hemoglobin concentration, serum tocopherol levels, reticulocyte count, H:Oz hemolysis test were carried out in 78 cases of low-birth-weight infants and 48 cases of normal infants at the age of 1 day, 1 week, 4 weeks and 8 weeks.
These infants were divided into 5 groups; the infants of group I, I, /, were weighing less than 2,000 g. at birth and W and V were more than 3,000 g.. All infants were fed commercial milk with high linoleic acid. Group j (28 cases) and N (23 cases) were control, group I (25 cases) was added vitamin-E and iron, and group 1 (25 cases) and V (25 cases) were given vitamin-E.
The results obtained were as follows;
1) Infants in group I showed significantly lower hemoglobin concentration and higher reticulocyte counts than other groups on the 4th and 8th week of life.
2) All infants receiving the commercial milk gave abnormally high H202-induced hemolysis and which seems to be decreased by vitamin-E supplementation.
3) Serum tocopherol levels on the 8th week of life showed the lowest level in group I (0.6 0.3mg/100ml) and there was no significant difference in other groups.
It appears that the anemia of low-birth-weight infants who were fed with formula milk was accelerated by early iron supplementation.
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